The WWC1 gene encodes the protein KIBRA, which helps modify the strength of the connections between your nerve cells. Variants of WWC1 may play a role in PTSD by changing your brain’s ability to ‘weaken’ or ‘forget’ certain stored traumatic memories. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing long-term potentiation/synaptic plasticity.
WWC1 rs10038727
- ‘G’ = associated with higher odds of PTSD
- ‘A’ = associated with decreased risk of current PTSD; associated with decreased risk of lifetime PTSD
WWC1 rs4576167
- ‘G’ = associated with higher odds of PTSD
- ‘C’ = associated with decreased risk of current PTSD; associated with decreased risk of lifetime PTSD
The two SNPs above appear to be linked; if you have the ‘G’ variant for one SNP, you probably have it for the other one as well [R].
For both of the above SNPs, the ‘G’ variant was associated with an approximately 2x increased risk of lifetime PTSD and a 3x increased risk of current PTSD [R]