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FKBP5

May Help: Sunshine exposure, CBT, Vitamin D, Stress Management

FKBP5 regulates parts of the immune system and basic cell function. It is also an important part of the stress response. It regulates the sensitivity of glucocorticoid receptors, meaning that it may alter the way that stress hormones affect the body [R, R].

Variants in FKBP5 have been linked to [R, R, R, R, R, R, R]:

  • PTSD (my genotypes are not associated with PTSD – Self Decode Report)
  • Response to medication in bipolar disorder
  • Systemic lupus erythematosus (SLE)
  • Major depressive disorder
  • Coronary artery disease
  • Alcohol withdrawal severity
  • Pain (My Genotypes are associated with pain disorders and chronic nerve pain)
  • Sunshine Exposure
  • Vitamin D
  • Stress Management
  • CBT

rs3800373 [R, R]: My Genotype AA

  • ‘C’ – associated with higher PTSD severity
  • ‘A’ – not associated with PTSD
  • This variant also correlates with chronic post-traumatic pain

rs1360780 [R]: My Genotype CC

  • ‘T’ – associated with higher PTSD severity
  • ‘C’ – not associated with PTSD

rs9470080 [R]: CC

  • ‘T’ – associated with higher PTSD severity
  • ‘C’ – not associated with PTSD

These variants increase FKBP5 expression and impair stress response. People carrying the risk alleles have a harder time recovering from childhood or early life traumas [R, R].

FKBP5 rs3800373 (AA 54%)

  • ‘A’ = Associated with chronic back pain
  • ‘C’ = Possibly protective against chronic back pain
  • The minor ‘C’ allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.

FKBP5 rs1360780 (CC 51%)

  • ‘C’ = Associated with chronic nerve pain (neuralgia)
  • ‘T’ = Possibly protective against neuralgia
  • The minor ‘T’ allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.

FKBP5 rs9394314 (AA 51%)

  • ‘A’ = Associated with chronic nerve pain (neuralgia)
  • ‘G’ = Possibly protective against neuralgia
  • The minor ‘G’ allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.

  • Variants in the FKBP5 gene have been associated with specific types of pain and pain disorders, including:
  • Back pain [R, R, R]
  • Post-traumatic chronic muscle pain [R, R, R]
  • Nerve pain [R, R]
  • Headaches [R, R]
  • Chest pain [R, R]
  • Neck and shoulder pain [R, R]
  • Increased use of painkillers [R, R]