The GSK3B gene plays a key role in regulating the overall activity of your brain’s serotonin system.
Your rs334558 genotype is associated with increased levels of the GSK3B enzyme, which has
complex effects on your overall risk of low mood and how well you respond to treatment.
Two of the best supplements for your genotype are zinc and bioavailable curcumin. Flavanoids can also help
The effects of the GSK3B gene are complex. On one hand, carriers of the ‘A’ allele for this SNP have GSK3B levels that are up to 1.4 times higher than average. Levels of GSK3B tend to be higher indepression patients, and inhibiting this enzyme reduces symptoms of depression and anxiety [185, 183].
This indicates that higher GSK3B levels are probably contributing to the development of mood disorders at least in some people