The IL4 gene encodes interleukin-4, an important inflammatory marker [R].
IL-4 is a proinflammatory cytokine. It stimulates the Th2 immune response, meaning that it promotes an antibody response to pathogens. High IL-4 levels may contribute to allergic reactions [R, R, R].
IL-4 also plays a role in DNA synthesis [R].
Variants in IL4 have been linked to [R, R, R]:
- Asthma
- Post-traumatic disorders
- Systemic lupus erythematosus