NR3C1 turns on other genes that are part of the stress response. It also plays a role in inflammation and cell reproduction [R, R].
Variants in NR3C1 are linked to [R]:
- Depression
- PTSD
- Anxiety
- Personality disorders
Variants of NR3C1 also have been associated with chronic fatigue syndrome, an illness characterized by prolonged low energy. These variants may lower sensitivity or activity of the glucocorticoid receptor, thus resulting in dysregulated HPA axis activity, excess cortisol release, and inflammation [R, R, R, R].
Primary SNP
NR3C1 rs852977 [R, R, R] My Genotype AA
- ‘A’ = Increased risk of chronic fatigue syndrome
- ‘G’ = Not associated with chronic fatigue syndrome
Other Important SNPs
NR3C1 rs1866388 [R, R, R] My Genotype AA
- ‘A’ = Increased risk of chronic fatigue syndrome
- ‘G’ = Not associated with chronic fatigue syndrome
NR3C1 rs6188 [R, R, R] My Genotype CC
- ‘C’ = Increased risk of chronic fatigue syndrome
- ‘A’ = Not associated with chronic fatigue syndrome
NR3C1 rs2918419 [R, R, R] My Genotype TT
- ‘T’ = Increased risk of chronic fatigue syndrome
- ‘C’ = Not associated with chronic fatigue syndrome
NR3C1 rs6196 [R, R, R] My Gentype AA
- ‘A’ = Increased risk of chronic fatigue syndrome
- ‘G’ = Not associated with chronic fatigue syndrome